• *Clara Dugan, 1st Southern Deputy
• *Lois Davis Tyrus, 2nd Southern Deputy/1st South Central Regional Director (1928 – 1930)
• *M. Viola Butler Taylor, 2nd South Central Regional Director (1930 – 1938)
• *Olivetta Jones Morgan, 3rd South Central Regional Director (1938 – 1941)
• *Connie Y. Conner, 4th South Central Regional Director (1941 – 1946)
• *Zephie C. Brooks, 5th South Central Regional Director (1946 – 1947)
• *Olive Durden Brown, 6th South Central Regional Director (1947 – 1951)
• *Eugene B. Long, 7th South Central Regional Director (1951 – 1955)
• *Odalie S. McDonald, 8th South Central Regional Director (1955 – 1959)
• *V. Besselle Atwell, 9th South Central Regional Director (1959 – 1961)
• *Odalie S. McDonald, 10th South CentralRegional Director (1961 – 1964)
• *Mattelia B. Grays, 11th South Central Regional Director (1964 – 1968)
• *Faye B. Bryant, 12th South Central Regional Director (1968 – 1972)
• Mary L. Williams, 13th South Central Regional Director (1972 – 1974)
• Deralyn Riles Davis, 14th South Central Regional Director (1974 – 1978)
• *Dorothy S. Johnson, 15th South Central Regional Director (1978 – 1982)
• *Mamie L. McKnight, 16th South Central Regional Director (1982 – 1986)
• *Jewel M. Thomas, 17th South Central Regional Director (1986 – 1990)
• Jacqueline Dansby, 18th South Central Regional Director (1990 – 1994)
• Carmelita C. Smith, 19th South Central Regional Director (1994 – 1996)
• *Polly Sparks Turner, 20th South Central Regional Director (1996 – 2000)
• Shirley R. Fisher, 21st South Central Regional Director (2000 – 2004)
• Tari T. Bradford, 22nd South Central Regional Director (2004 – 2008)
• Gwendolyn J. Brinkley, 23rd South Central Regional Director (2008 – 2012)
• Chelle L. Wilson, 24th South Central Regional Director (2012 – 2016)
• Katina Semien Smothers, 25th South Central Regional Director (2016 – 2020)
• Joya T. Hayes, Current South Central Regional Director (2020 – Present)

*Indicates Deceased